Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50318633
Substrate
n/a
Meas. Tech.
ChEMBL_1923441 (CHEMBL4426397)
Ki
0.234000±n/a nM
Citation
 Zajdel, P; Marciniec, K; Sata?a, G; Canale, V; Kos, T; Partyka, A; Jastrz?bska-Wi?sek, M; Weso?owska, A; Basi?ska-Ziobro?, A; Wójcikowski, J; Daniel, WA; Bojarski, AJ; Popik, P N1-Azinylsulfonyl-1H-indoles: 5-HT6 Receptor Antagonists with Procognitive and Antidepressant-Like Properties. ACS Med Chem Lett 7:618-22 (2016) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 | 5HT6R_RAT | Htr6 | ST-B17 | Serotonin (5-HT) receptor | Serotonin 6 (5-HT6) receptor | Serotonin receptor 6
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46945.51
Organism:
RAT
Description:
5-HT6 HTR6 RAT::P31388
Residue:
436
Sequence:
MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
  
Inhibitor
Name:
BDBM50318633
Synonyms:
3-benzenesulfonyl-8-piperazin-1-ylquinoline | CHEMBL1083390 | SB-742457
Type:
Small organic molecule
Emp. Form.:
C19H19N3O2S
Mol. Mass.:
353.438
SMILES:
O=S(=O)(c1ccccc1)c1cnc2c(cccc2c1)N1CCNCC1
Structure:
Search PDB for entries with ligand similarity: