Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50089032
Substrate
n/a
Meas. Tech.
ChEBML_143988
IC50
58±n/a nM
Citation
 Rueeger, H; Rigollier, P; Yamaguchi, Y; Schmidlin, T; Schilling, W; Criscione, L; Whitebread, S; Chiesi, M; Walker, MW; Dhanoa, D; Islam, I; Zhang, J; Gluchowski, C Design, synthesis and SAR of a series of 2-substituted 4-amino-quinazoline neuropeptide Y Y5 receptor antagonists. Bioorg Med Chem Lett 10:1175-9 (2000) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50089032
Synonyms:
CHEMBL17395 | N-{4-[4-(4-Chloro-phenylamino)-quinazolin-2-ylamino]-cyclohexylmethyl}-N-methyl-acetamide
Type:
Small organic molecule
Emp. Form.:
C24H28ClN5O
Mol. Mass.:
437.965
SMILES:
CN(C[C@H]1CC[C@@H](CC1)Nc1nc(Nc2ccc(Cl)cc2)c2ccccc2n1)C(C)=O |wU:6.9,wD:3.2,(15.46,-3.75,;14.14,-4.52,;12.79,-3.76,;11.46,-4.52,;10.13,-3.76,;8.78,-4.54,;8.8,-6.08,;10.13,-6.84,;11.46,-6.08,;7.46,-6.85,;6.12,-6.08,;6.11,-4.54,;4.77,-3.78,;4.76,-2.23,;6.1,-1.45,;7.43,-2.22,;8.76,-1.44,;8.75,.11,;10.09,.88,;7.4,.86,;6.08,.09,;3.44,-4.55,;2.1,-3.78,;.77,-4.55,;.77,-6.11,;2.1,-6.87,;3.44,-6.1,;4.78,-6.87,;14.14,-6.08,;15.48,-6.83,;12.8,-6.84,)|
Structure:
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