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Target
Neuropeptide Y receptor type 1
Ligand
BDBM50089035
Substrate
n/a
Meas. Tech.
ChEBML_143672
IC50
60000±n/a nM
Citation
 Rueeger, H; Rigollier, P; Yamaguchi, Y; Schmidlin, T; Schilling, W; Criscione, L; Whitebread, S; Chiesi, M; Walker, MW; Dhanoa, D; Islam, I; Zhang, J; Gluchowski, C Design, synthesis and SAR of a series of 2-substituted 4-amino-quinazoline neuropeptide Y Y5 receptor antagonists. Bioorg Med Chem Lett 10:1175-9 (2000) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50089035
Synonyms:
2-[1-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperidin-4-yl]-2,3-dihydro-isoindol-1-one | CHEMBL18016
Type:
Small organic molecule
Emp. Form.:
C23H25N5O3
Mol. Mass.:
419.4763
SMILES:
COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)N1Cc2ccccc2C1=O
Structure:
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