Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50089052
Substrate
n/a
Meas. Tech.
ChEBML_143988
IC50
400±n/a nM
Citation
 Rueeger, H; Rigollier, P; Yamaguchi, Y; Schmidlin, T; Schilling, W; Criscione, L; Whitebread, S; Chiesi, M; Walker, MW; Dhanoa, D; Islam, I; Zhang, J; Gluchowski, C Design, synthesis and SAR of a series of 2-substituted 4-amino-quinazoline neuropeptide Y Y5 receptor antagonists. Bioorg Med Chem Lett 10:1175-9 (2000) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50089052
Synonyms:
Benzoic acid 4-(4-phenylamino-quinazolin-2-ylamino)-cyclohexyl ester | CHEMBL17496
Type:
Small organic molecule
Emp. Form.:
C27H26N4O2
Mol. Mass.:
438.5209
SMILES:
O=C(O[C@H]1CC[C@@H](CC1)Nc1nc(Nc2ccccc2)c2ccccc2n1)c1ccccc1 |wU:6.9,wD:3.2,(17.99,-6.34,;16.66,-7.1,;15.32,-6.35,;13.99,-7.13,;12.66,-6.35,;11.31,-7.13,;11.34,-8.68,;12.66,-9.43,;13.99,-8.66,;9.99,-9.45,;8.66,-8.68,;8.66,-7.13,;7.31,-6.36,;7.31,-4.82,;8.64,-4.03,;8.62,-2.51,;9.94,-1.73,;11.29,-2.49,;11.29,-4.03,;9.96,-4.82,;5.99,-7.14,;4.64,-6.37,;3.31,-7.14,;3.31,-8.69,;4.64,-9.47,;5.99,-8.69,;7.34,-9.45,;16.66,-8.64,;17.99,-9.4,;18.01,-10.92,;16.69,-11.71,;15.34,-10.94,;15.34,-9.41,)|
Structure:
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