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Target
Polyphenol oxidase 2
Ligand
BDBM50041234
Substrate
n/a
Meas. Tech.
ChEMBL_1927666 (CHEMBL4430738)
EC50
14800±n/a nM
Citation
 Niu, C; Yin, L; Nie, LF; Dou, J; Zhao, JY; Li, G; Aisa, HA Synthesis and bioactivity of novel isoxazole chalcone derivatives on tyrosinase and melanin synthesis in murine B16 cells for the treatment of vitiligo. Bioorg Med Chem 24:5440-5448 (2016) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50041234
Synonyms:
6-hydroxy-7-methoxy-5-benzofuranacrylic acid delta-lactone | 8-MP | 8-methoxy-2',3',6,7-furocoumarin | 8-methoxy-4',5':6,7-furocoumarin | 8-methoxy-[furano-3'.2':6.7-coumarin] | 8-methoxypsoralen | 9-methoxy-7H-furo[3,2-g][1]benzopyran-7-one | 9-methoxy-7H-furo[3,2-g]chromen-7-one | CHEMBL416 | METHOXSALEN | xanthotoxin
Type:
Small organic molecule
Emp. Form.:
C12H8O4
Mol. Mass.:
216.1895
SMILES:
COc1c2occc2cc2ccc(=O)oc12
Structure:
Search PDB for entries with ligand similarity: