Reaction Details Report a problem with these data
Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50534294
Substrate
n/a
Meas. Tech.
ChEMBL_1928143 (CHEMBL4431215)
Ki
6.0±n/a nM
Citation
 Sarasamkan, J; Scheunemann, M; Apaijai, N; Palee, S; Parichatikanond, W; Arunrungvichian, K; Fischer, S; Chattipakorn, S; Deuther-Conrad, W; Schüürmann, G; Brust, P; Vajragupta, O Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds. ACS Med Chem Lett 7:890-895 (2016) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) | Neuronal acetylcholine receptor | ACHA7_RAT | Chrna7 | Acra7
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rat
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50534294
Synonyms:
CHEMBL4460057
Type:
Small organic molecule
Emp. Form.:
C16H19N3O
Mol. Mass.:
269.35
SMILES:
O=C(N[C@H]1CN2CCC1CC2)c1c[nH]c2ccccc12 |r,wU:3.2,THB:2:3:6.7:10.9,(32.16,-42.25,;32.18,-40.71,;30.86,-39.92,;29.51,-40.67,;29.31,-42.06,;27.78,-41.4,;26.41,-42.03,;26.69,-40.64,;28.04,-40.03,;27.97,-38.39,;27.52,-39.5,;33.53,-39.96,;33.71,-38.42,;35.22,-38.12,;35.98,-39.47,;37.47,-39.81,;37.93,-41.27,;36.88,-42.41,;35.38,-42.06,;34.92,-40.59,)|
Structure:
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