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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50534283
Substrate
n/a
Meas. Tech.
ChEMBL_1928132 (CHEMBL4431204)
Ki
97±n/a nM
Citation
 Sarasamkan, J; Scheunemann, M; Apaijai, N; Palee, S; Parichatikanond, W; Arunrungvichian, K; Fischer, S; Chattipakorn, S; Deuther-Conrad, W; Schüürmann, G; Brust, P; Vajragupta, O Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds. ACS Med Chem Lett 7:890-895 (2016) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
Cholinergic, Nicotinic Alpha7 | NACHRA7 | nAChR7 | CHRNA7 | Nicotinic acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR) | ACHA7_HUMAN | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Human
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50534283
Synonyms:
CHEMBL4440403
Type:
Small organic molecule
Emp. Form.:
C18H23FN4O
Mol. Mass.:
330.41
SMILES:
FCCCOc1cccc(c1)-c1cn(nn1)[C@@H]1CN2CCC1CC2 |r,wD:16.17,THB:13:16:19.20:23.22,(52.12,-36.97,;51.34,-38.3,;49.8,-38.29,;49.03,-39.62,;47.49,-39.61,;46.72,-38.27,;47.5,-36.94,;46.73,-35.6,;45.19,-35.6,;44.42,-36.93,;45.18,-38.27,;42.88,-36.92,;41.84,-38.05,;40.44,-37.41,;40.62,-35.88,;42.13,-35.58,;39.1,-38.16,;38.89,-39.54,;37.36,-38.88,;35.99,-39.51,;36.28,-38.12,;37.62,-37.52,;37.56,-35.88,;37.1,-36.99,)|
Structure:
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