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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50534302
Substrate
n/a
Meas. Tech.
ChEMBL_1928132 (CHEMBL4431204)
Ki
23±n/a nM
Citation
 Sarasamkan, J; Scheunemann, M; Apaijai, N; Palee, S; Parichatikanond, W; Arunrungvichian, K; Fischer, S; Chattipakorn, S; Deuther-Conrad, W; Schüürmann, G; Brust, P; Vajragupta, O Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds. ACS Med Chem Lett 7:890-895 (2016) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
Cholinergic, Nicotinic Alpha7 | NACHRA7 | nAChR7 | CHRNA7 | Nicotinic acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR) | ACHA7_HUMAN | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Human
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50534302
Synonyms:
CHEMBL4463888
Type:
Small organic molecule
Emp. Form.:
C22H24N4O
Mol. Mass.:
360.46
SMILES:
C(Oc1cccc(c1)-c1cn(nn1)[C@H]1CN2CCC1CC2)c1ccccc1 |r,wU:13.14,THB:10:13:16.17:20.19,(30.56,-47.26,;29.02,-47.25,;28.26,-45.91,;29.03,-44.58,;28.26,-43.24,;26.72,-43.24,;25.96,-44.57,;26.72,-45.91,;24.42,-44.56,;23.37,-45.69,;21.97,-45.05,;22.15,-43.52,;23.66,-43.22,;20.62,-45.79,;20.42,-47.18,;18.89,-46.52,;17.52,-47.15,;17.8,-45.76,;19.15,-45.15,;19.09,-43.52,;18.63,-44.63,;31.33,-48.6,;30.54,-49.92,;31.31,-51.26,;32.85,-51.27,;33.63,-49.93,;32.86,-48.6,)|
Structure:
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