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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50534301
Substrate
n/a
Meas. Tech.
ChEMBL_1928132 (CHEMBL4431204)
Ki
39±n/a nM
Citation
 Sarasamkan, J; Scheunemann, M; Apaijai, N; Palee, S; Parichatikanond, W; Arunrungvichian, K; Fischer, S; Chattipakorn, S; Deuther-Conrad, W; Schüürmann, G; Brust, P; Vajragupta, O Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds. ACS Med Chem Lett 7:890-895 (2016) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
Cholinergic, Nicotinic Alpha7 | NACHRA7 | nAChR7 | CHRNA7 | Nicotinic acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR) | ACHA7_HUMAN | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Human
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50534301
Synonyms:
CHEMBL4474896
Type:
Small organic molecule
Emp. Form.:
C17H21FN4O
Mol. Mass.:
316.38
SMILES:
FCCOc1cccc(c1)-c1cn(nn1)[C@H]1CN2CCC1CC2 |r,wU:15.16,THB:12:15:18.19:22.21,(32.59,-29.82,;31.05,-29.81,;30.27,-31.14,;28.73,-31.13,;27.97,-29.8,;28.75,-28.46,;27.97,-27.12,;26.44,-27.12,;25.67,-28.45,;26.43,-29.79,;24.13,-28.45,;23.08,-29.58,;21.68,-28.93,;21.87,-27.4,;23.38,-27.1,;20.34,-29.68,;20.14,-31.06,;18.6,-30.4,;17.24,-31.04,;17.52,-29.64,;18.87,-29.04,;18.8,-27.4,;18.35,-28.51,)|
Structure:
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