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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50534296
Substrate
n/a
Meas. Tech.
ChEMBL_1928132 (CHEMBL4431204)
Ki
127±n/a nM
Citation
 Sarasamkan, J; Scheunemann, M; Apaijai, N; Palee, S; Parichatikanond, W; Arunrungvichian, K; Fischer, S; Chattipakorn, S; Deuther-Conrad, W; Schüürmann, G; Brust, P; Vajragupta, O Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds. ACS Med Chem Lett 7:890-895 (2016) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
Cholinergic, Nicotinic Alpha7 | NACHRA7 | nAChR7 | CHRNA7 | Nicotinic acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR) | ACHA7_HUMAN | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Human
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50534296
Synonyms:
CHEMBL4557590
Type:
Small organic molecule
Emp. Form.:
C22H23FN4O
Mol. Mass.:
378.45
SMILES:
Fc1ccc(COc2cccc(c2)-c2cn(nn2)C2CN3CCC2CC3)cc1 |THB:15:18:21.22:25.24,(15.78,-52.49,;15.01,-51.15,;13.47,-51.14,;12.71,-49.81,;13.49,-48.48,;12.72,-47.14,;11.18,-47.14,;10.42,-45.8,;11.2,-44.46,;10.42,-43.12,;8.89,-43.12,;8.12,-44.45,;8.88,-45.79,;6.58,-44.45,;5.53,-45.58,;4.13,-44.93,;4.31,-43.4,;5.83,-43.1,;2.79,-45.68,;2.58,-47.07,;1.05,-46.41,;-.33,-47.04,;-.04,-45.64,;1.31,-45.04,;1.25,-43.4,;.79,-44.51,;15.02,-48.48,;15.79,-49.81,)|
Structure:
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