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Target
E3 ubiquitin-protein ligase XIAP
Ligand
BDBM50535120
Substrate
n/a
Meas. Tech.
ChEMBL_1929902 (CHEMBL4433078)
IC50
370±n/a nM
Citation
 Manzoni, L; Gornati, D; Manzotti, M; Cairati, S; Bossi, A; Arosio, D; Lecis, D; Seneci, P Dual action Smac mimetics-zinc chelators as pro-apoptotic antitumoral agents. Bioorg Med Chem Lett 26:4613-4619 (2016) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase XIAP
Synonyms:
Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | E3 ubiquitin-protein ligase XIAP | X-linked inhibitor of apoptosis | XIAP_HUMAN | XIAP | API3 | BIRC4 | IAP3 | X-linked inhibitor of apoptosis protein (XIAP)
Type:
Protein
Mol. Mass.:
56685.27
Organism:
Human
Description:
P98170
Residue:
497
Sequence:
MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS
  
Inhibitor
Name:
BDBM50535120
Synonyms:
CHEMBL4451097
Type:
Small organic molecule
Emp. Form.:
C43H50N8O5
Mol. Mass.:
758.92
SMILES:
[H][C@]12CC[C@H](N1C(=O)[C@@H](NC(=O)[C@H](CC)NC)[C@@H](CNC(=O)c1ccccc1)CC2)C(=O)N[C@H](C(=O)N(Cc1ccccn1)Cc1ccccn1)c1ccccc1 |r|
Structure:
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