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Target
Nuclear receptor ROR-gamma
Ligand
BDBM50536796
Substrate
n/a
Meas. Tech.
ChEMBL_1934537 (CHEMBL4480189)
EC50
6.0±n/a nM
Citation
 René, O; Fauber, BP; Barnard, A; Chapman, K; Deng, Y; Eidenschenk, C; Everett, C; Gobbi, A; Johnson, AR; La, H; Norman, M; Salmon, G; Summerhill, S; Wong, H Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties. Bioorg Med Chem Lett 26:4455-4461 (2016) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) | Nuclear receptor ROR-gamma (RORC) | RORG_HUMAN | RORC | NR1F3 | RORG | RZRG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Human
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM50536796
Synonyms:
CHEMBL4560046
Type:
Small organic molecule
Emp. Form.:
C24H30FN3O3S
Mol. Mass.:
459.59
SMILES:
CC(=O)N1CCN(CC1)c1ccc(CN2CCCC[C@H](c3ccccc3)S2(=O)=O)c(F)c1 |r|
Structure:
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