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Target
Nuclear receptor ROR-alpha
Ligand
BDBM50536796
Substrate
n/a
Meas. Tech.
ChEMBL_1934544 (CHEMBL4480196)
EC50
6800±n/a nM
Citation
 René, O; Fauber, BP; Barnard, A; Chapman, K; Deng, Y; Eidenschenk, C; Everett, C; Gobbi, A; Johnson, AR; La, H; Norman, M; Salmon, G; Summerhill, S; Wong, H Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties. Bioorg Med Chem Lett 26:4455-4461 (2016) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-alpha
Synonyms:
RORA_HUMAN | RORA | NR1F1 | RZRA | Nuclear receptor subfamily 1 group F member 1 | RAR-related orphan receptor A | Retinoid-related orphan receptor-alpha | Nuclear receptor RZR-alpha
Type:
PROTEIN
Mol. Mass.:
58976.26
Organism:
Human
Description:
ChEMBL_101591
Residue:
523
Sequence:
MESAPAAPDPAASEPGSSGADAAAGSRETPLNQESARKSEPPAPVRRQSYSSTSRGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
  
Inhibitor
Name:
BDBM50536796
Synonyms:
CHEMBL4560046
Type:
Small organic molecule
Emp. Form.:
C24H30FN3O3S
Mol. Mass.:
459.59
SMILES:
CC(=O)N1CCN(CC1)c1ccc(CN2CCCC[C@H](c3ccccc3)S2(=O)=O)c(F)c1 |r|
Structure:
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