Target
Nuclear receptor ROR-gamma
Ligand
BDBM50537148
Substrate
n/a
Meas. Tech.
ChEMBL_1935804 (CHEMBL4481563)
EC50
>20000±n/a nM
Citation
 Kotoku, MMaeba, TFujioka, SYokota, MSeki, NIto, KSuwa, YIkenogami, THirata, KHase, YKatsuda, YMiyagawa, NArita, KAsahina, KNoguchi, MNomura, ADoi, SAdachi, TCrowe, PTao, HThacher, SHashimoto, HSuzuki, TShiozaki, M Discovery of Second Generation ROR? Inhibitors Composed of an Azole Scaffold. J Med Chem 62:2837-2842 (2019) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM50537148
Synonyms:
CHEMBL4544876
Type:
Small organic molecule
Emp. Form.:
C25H36N4O3
Mol. Mass.:
440.5783
SMILES:
CC(C)CCCc1nnc(C(CCC(O)=O)CC(=O)Nc2ccc(C)cc2C)n1C1CC1
Structure:
Search PDB for entries with ligand similarity: