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Target
Beta-lactamase
Ligand
BDBM50537176
Substrate
n/a
Meas. Tech.
ChEMBL_1935934 (CHEMBL4481693)
KON
16000 M-1s-1
Citation
 Malico, AA; Dave, K; Adediran, SA; Pratt, RF Specificity of extended O-aryloxycarbonyl hydroxamates as inhibitors of a class C β-lactamase. Bioorg Med Chem 27:1430-1436 (2019) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
AMPC_ENTCL | ampC
Type:
PROTEIN
Mol. Mass.:
41306.67
Organism:
Enterobacter cloacae
Description:
ChEMBL_40258
Residue:
381
Sequence:
MMRKSLCCALLLGISCSALATPVSEKQLAEVVANTITPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDAVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILEALQ
  
Inhibitor
Name:
BDBM50537176
Synonyms:
CHEMBL4535968
Type:
Small organic molecule
Emp. Form.:
C13H16N2O7
Mol. Mass.:
312.28
SMILES:
N[C@H](CCCOC(=O)NOC(=O)Oc1ccccc1)C(O)=O |r|
Structure:
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