Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 8
Ligand
BDBM50180512
Substrate
n/a
Meas. Tech.
ChEMBL_1936429 (CHEMBL4482188)
IC50
22700±n/a nM
Citation
 Li, X; Qiao, Y; Wang, X; Ma, R; Li, T; Zhang, Y; Borris, RP Dihydrophenanthrenes from Juncus effusus as Inhibitors of OAT1 and OAT3. J Nat Prod 82:832-839 (2019) [PubMed]  Article 
Target
Name:
Solute carrier family 22 member 8
Synonyms:
Organic anion transporter 3 | hOAT3 | S22A8_HUMAN | SLC22A8 | OAT3
Type:
PROTEIN
Mol. Mass.:
59870.13
Organism:
Human
Description:
ChEMBL_1486920
Residue:
542
Sequence:
MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPWVLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLGSS
  
Inhibitor
Name:
BDBM50180512
Synonyms:
1-methyl-5-vinyl-9,10-dihydrophenanthrene-2,7-diol | CHEMBL205119
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Cc1c(O)ccc-2c1CCc1cc(O)cc(C=C)c-21
Structure:
Search PDB for entries with ligand similarity: