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Target
Metallo-beta-lactamase type 2
Ligand
BDBM262417
Substrate
n/a
Meas. Tech.
ChEMBL_2609400
IC50
0.900000±n/a nM
Citation
 Bennett, F; Huang, Y; Dong, S; Jiang, J; Hunter, D; Zhao, Z; Gu, X; Scott, JD; Tang, H; Yang, D; Xiao, L; Scapin, G; Fischmann, T; Mirza, A; Dayananth, P; Painter, RE; Villafania, A; Garlisi, CG; Zhang, R; Mayhood, TW; Si, Q; Li, N; Amin, RP; Chen, F; Bhatt, B; Regan, CP; Regan, H; Lin, X; Wu, J; Leithead, A; Young, K; Pasternak, A Discovery of sulfone containing metallo-β-lactamase inhibitors with reduced bacterial cell efflux and histamine release issues. Bioorg Med Chem Lett 114:0[PubMed] 
Target
Name:
Metallo-beta-lactamase type 2
Synonyms:
B2 metallo-beta-lactamase | Beta-lactamase type II | Metallo-beta-lactamase NDM-1 | Metallo-beta-lactamase type 2 | Metallo-beta-lactamase type II | NDM-1 | New Delhi metallo-beta-lactamase-1 | Beta-lactamase NDM-1 | BLAN1_KLEPN | blaNDM-1
Type:
PROTEIN
Mol. Mass.:
28498.15
Organism:
Pseudomonas aeruginosa (g-Proteobacteria)
Description:
ChEMBL_103887
Residue:
270
Sequence:
MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR
  
Inhibitor
Name:
BDBM262417
Synonyms:
US9708336, 269
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
452.12
SMILES:
NS(=O)(=O)c1c(C(F)(F)F)ccc(-c2ccc(C3CCNCC3)cc2)c1-c1nn[nH]n1
Structure:
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