Reaction Details Report a problem with these data
Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50058655
Substrate
n/a
Meas. Tech.
ChEMBL_1981922 (CHEMBL4615184)
IC50
1200±n/a nM
Citation
Huang, Y; Xu, Y; Song, R; Ni, S; Liu, J; Xu, Y; Ren, Y; Rao, L; Wang, Y; Wei, L; Feng, L; Su, C; Peng, C; Li, J; Wan, J Identification of the New Covalent Allosteric Binding Site of Fructose-1,6-bisphosphatase with Disulfiram Derivatives toward Glucose Reduction. J Med Chem 63:6238-6247 (2020) [PubMed] Article
More Info.:
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Homo sapiens (Human)
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
Inhibitor
Name:
BDBM50058655
Synonyms:
1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane | 1,1'-dithiobis(N,N-diethylthioformamide) | Antabuse (TN) | CHEMBL964 | DISULFIRAM | Disul-firam | N,N,N',N'-tetraethylthiuram disulfide | N,N-diethyl[(diethylcarbamothioyl)disulfanyl]carbothioamide (G5) | US11753371, Compound II-2a-(Disulfiram) | US20230414581, Compound 37 | bis(diethylthiocarbamoyl) disulfide | cid_3117 | med.21724, Compound 151 | tetraethylthioperoxydicarbonic diamide | tetraethylthiuram disulfide | tetraethylthiuram disulphide
Type:
Small organic molecule
Emp. Form.:
C10H20N2S4
Mol. Mass.:
296.539
SMILES:
CCN(CC)C(=S)SSC(=S)N(CC)CC