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Target
Carbonic anhydrase 2
Ligand
BDBM50540616
Substrate
n/a
Meas. Tech.
ChEMBL_1982499 (CHEMBL4615761)
Ki
80±n/a nM
Citation
 Pratesi, D; Matassini, C; Goti, A; Angeli, A; Carta, F; Supuran, CT; Spanevello, R; Cardona, F Glycomimetic Based Approach toward Selective Carbonic Anhydrase Inhibitors. ACS Med Chem Lett 11:727-731 (2020) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50540616
Synonyms:
CHEMBL4643051
Type:
Small organic molecule
Emp. Form.:
C23H36N6O5S
Mol. Mass.:
508.634
SMILES:
[H][C@@]12CN(CCCCCCn3cc(CNc4ccc(cc4)S(N)(=O)=O)nn3)C[C@@H](O)[C@]1([H])OC(C)(C)O2 |r|
Structure:
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