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Target
Carbonic anhydrase 6
Ligand
BDBM50540616
Substrate
n/a
Meas. Tech.
ChEMBL_1982503 (CHEMBL4615765)
Ki
69±n/a nM
Citation
 Pratesi, D; Matassini, C; Goti, A; Angeli, A; Carta, F; Supuran, CT; Spanevello, R; Cardona, F Glycomimetic Based Approach toward Selective Carbonic Anhydrase Inhibitors. ACS Med Chem Lett 11:727-731 (2020) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 6
Synonyms:
CA-VI | CA6 | CAH6_HUMAN | Carbonate dehydratase VI | Carbonic Anhydrase VI | Carbonic anhydrase | Carbonic anhydrase 6 | Carbonic anhydrase 6 (CA VI) | Carbonic anhydrase 6 (CA-VI) | Carbonic anhydrase VI (CA VI) | Salivary carbonic anhydrase | Secreted carbonic anhydrase
Type:
Enzyme
Mol. Mass.:
35371.40
Organism:
Homo sapiens (Human)
Description:
P23280
Residue:
308
Sequence:
MRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPACGGQRQSPINLQRTKVRYNPSLKGLNMTGYETQAGEFPMVNNGHTVQISLPSTMRMTVADGTVYIAQQMHFHWGGASSEISGSEHTVDGIRHVIEIHIVHYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNFISHLANIKYPGQRTTLTGLDVQDMLPRNLQHYYTYHGSLTTPPCTENVHWFVLADFVKLSRTQVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEYTLGSEFQFYLHKIEEILDYLRRALN
  
Inhibitor
Name:
BDBM50540616
Synonyms:
CHEMBL4643051
Type:
Small organic molecule
Emp. Form.:
C23H36N6O5S
Mol. Mass.:
508.634
SMILES:
[H][C@@]12CN(CCCCCCn3cc(CNc4ccc(cc4)S(N)(=O)=O)nn3)C[C@@H](O)[C@]1([H])OC(C)(C)O2 |r|
Structure:
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