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Target
Substance-K receptor
Ligand
BDBM50096951
Substrate
n/a
Meas. Tech.
ChEBML_141789
Ki
11±n/a nM
Citation
 Ting, PC; Lee, JF; Anthes, JC; Shih, NY; Piwinski, JJ Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors. Bioorg Med Chem Lett 11:491-4 (2001) [PubMed]  Article  BDB Entry
Target
Name:
Substance-K receptor
Synonyms:
NK-2 receptor | NK-2R | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3
Type:
Protein
Mol. Mass.:
44455.78
Organism:
Homo sapiens (Human)
Description:
P21452
Residue:
398
Sequence:
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
  
Inhibitor
Name:
BDBM50096951
Synonyms:
1'-{5-(3,5-Bis-trifluoromethyl-benzyloxy)-3-(3,4-dichloro-phenyl)-4-[(Z)-methoxyimino]-pentyl}-[1,4']bipiperidinyl-3-carboxylic acid amide | CHEMBL342341
Type:
Small organic molecule
Emp. Form.:
C32H38Cl2F6N4O3
Mol. Mass.:
711.566
SMILES:
CO\N=C(/COCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(CCN1CCC(CC1)N1CCCC(C1)C(N)=O)c1ccc(Cl)c(Cl)c1
Structure:
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