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Target
Alpha-enolase
Ligand
BDBM50543112
Substrate
n/a
Meas. Tech.
ChEMBL_1988448 (CHEMBL4621995)
IC50
2554±n/a nM
Citation
 Yan, VC; Yang, KL; Ballato, ES; Khadka, S; Shrestha, P; Arthur, K; Georgiou, DK; Washington, M; Tran, T; Poral, AH; Pham, CD; Yan, MJ; Muller, FL Bioreducible Phosphonoamidate Pro-drug Inhibitor of Enolase: Proof of Concept Study. ACS Med Chem Lett 11:1484-1489 (2020) [PubMed]  Article 
Target
Name:
Alpha-enolase
Synonyms:
2-phospho-D-glycerate hydro-lyase | 4.2.1.11 | C-myc promoter-binding protein | ENO1 | ENO1L1 | ENOA_HUMAN | Enolase 1 | Enolase 1 (ENO1) | MBP-1 | MBPB1 | MPB-1 | MPB1 | NNE | Non-neural enolase | Phosphopyruvate hydratase | Plasminogen-binding protein
Type:
n/a
Mol. Mass.:
47171.43
Organism:
Homo sapiens (Human)
Description:
P06733
Residue:
434
Sequence:
MSILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNSEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAGYTDKVVIGMDVAASEFFRSGKYDLDFKSPDDPSRYISPDQLADLYKSFIKDYPVVSIEDPFDQDDWGAWQKFTASAGIQVVGDDLTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVTESLQACKLAQANGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLLRIEEELGSKAKFAGRNFRNPLAK
  
Inhibitor
Name:
BDBM50543112
Synonyms:
Evofosfamide | HAP-302 | TH-302
Type:
Small organic molecule
Emp. Form.:
C9H16Br2N5O4P
Mol. Mass.:
449.036
SMILES:
Cn1c(COP(=O)(NCCBr)NCCBr)cnc1[N+]([O-])=O
Structure:
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