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Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM50543775
Substrate
n/a
Meas. Tech.
ChEMBL_1989847 (CHEMBL4623582)
Kd
18±n/a nM
Citation
 Golojuch, S; Kopcial, M; Strzelecka, D; Kasprzyk, R; Baran, N; Sikorski, PJ; Kowalska, J; Jemielity, J Exploring tryptamine conjugates as pronucleotides of phosphate-modified 7-methylguanine nucleotides targeting cap-dependent translation. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
IF4E_MOUSE | Eif4e
Type:
PROTEIN
Mol. Mass.:
25051.39
Organism:
Mouse
Description:
ChEMBL_627826
Residue:
217
Sequence:
MATVEPETTPTTNPPPAEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENRDAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM50543775
Synonyms:
CHEMBL4640985
Type:
Small organic molecule
Emp. Form.:
C11H17N5O10P2S
Mol. Mass.:
473.30
SMILES:
C[n+]1cn([C@@H]2O[C@H](COP(S)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c2nc(N)nc([O-])c12 |r|
Structure:
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