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Target
m7GpppX diphosphatase
Ligand
BDBM50543779
Substrate
n/a
Meas. Tech.
ChEMBL_1989853 (CHEMBL4623588)
Ki
740±n/a nM
Citation
 Golojuch, S; Kopcial, M; Strzelecka, D; Kasprzyk, R; Baran, N; Sikorski, PJ; Kowalska, J; Jemielity, J Exploring tryptamine conjugates as pronucleotides of phosphate-modified 7-methylguanine nucleotides targeting cap-dependent translation. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
m7GpppX diphosphatase
Synonyms:
DCPS_HUMAN | DCPS | DCS1 | HINT5 | Scavenger mRNA-decapping enzyme (DcpS)
Type:
Enzyme
Mol. Mass.:
38606.80
Organism:
Human
Description:
Q96C86
Residue:
337
Sequence:
MADAAPQLGKRKRELDVEEAHAASTEEKEAGVGNGTCAPVRLPFSGFRLQKVLRESARDKIIFLHGKVNEASGDGDGEDAVVILEKTPFQVEQVAQLLTGSPELQLQFSNDIYSTYHLFPPRQLNDVKTTVVYPATEKHLQKYLRQDLRLIRETGDDYRNITLPHLESQSLSIQWVYNILDKKAEADRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNILHQGQEAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLLAEVIENLECDPRHYQQRTLTFALRADDPLLKLLQEAQQS
  
Inhibitor
Name:
BDBM50543779
Synonyms:
CHEMBL4635767
Type:
Small organic molecule
Emp. Form.:
C21H33N9O9P2S
Mol. Mass.:
649.56
SMILES:
C[n+]1cn([C@@H]2O[C@H](COP(S)(=O)OP(O)(=O)NCCc3c[nH]c4ccccc34)[C@@H](O)[C@H]2O)c2nc(N)nc([O-])c12
Structure:
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