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Target
Chymase
Ligand
BDBM50101136
Substrate
n/a
Meas. Tech.
ChEBML_197650
IC50
0.850000±n/a nM
Citation
 Aoyama, Y; Uenaka, M; Konoike, T; Hayasaki-Kajiwara, Y; Naya, N; Nakajima, M Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones. Bioorg Med Chem Lett 11:1691-4 (2001) [PubMed]  Article 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM50101136
Synonyms:
1,3-Bis-benzo[1,3]dioxol-5-ylmethyl-[1,3]diazetidine-2,4-dione | CHEMBL44950
Type:
Small organic molecule
Emp. Form.:
C18H14N2O6
Mol. Mass.:
354.3136
SMILES:
O=C1N(Cc2ccc3OCOc3c2)C(=O)N1Cc1ccc2OCOc2c1
Structure:
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