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Target
Endothelin-1 receptor
Ligand
BDBM50101264
Substrate
n/a
Meas. Tech.
ChEBML_65627
IC50
96±n/a nM
Citation
 Kukkola, PJ; Bilci, NA; Ikler, T; Savage, P; Shetty, SS; DelGrande, D; Jeng, AY Isoindolines: a new series of potent and selective endothelin-A receptor antagonists. Bioorg Med Chem Lett 11:1737-40 (2001) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48736.88
Organism:
Homo sapiens (Human)
Description:
P25101
Residue:
427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
  
Inhibitor
Name:
BDBM50101264
Synonyms:
CHEMBL298664 | [(1R,3R)-1-Benzo[1,3]dioxol-5-yl-3-(2-carboxymethoxy-3,4-dimethoxy-phenyl)-5-ethoxy-1,3-dihydro-isoindol-2-yl]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C29H29NO10
Mol. Mass.:
551.5413
SMILES:
CCOc1ccc2[C@H](N(CC(O)=O)[C@H](c2c1)c1ccc(OC)c(OC)c1OCC(O)=O)c1ccc2OCOc2c1
Structure:
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