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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM21393
Substrate
n/a
Meas. Tech.
ChEMBL_1991786 (CHEMBL4625521)
Ki
0.800000±n/a nM
Citation
 Karki, A; Namballa, HK; Alberts, I; Harding, WW Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HT Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | G-21 | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5-HT-1A | 5-HT1A | HTR1A | Serotonin receptor 1A | Dopamine D2 receptor and serotonin 1a receptor
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Human
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM21393
Synonyms:
cid_1220 | CHEMBL56 | 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol | CHEMBL505765 | DPAT | 8-OH-DPAT,(-) | 8-OH-DPAT,(+) | 8-OH-DPAT | 8-hydroxy-N,N-dipropylaminotetralin | 8-Hydroxy-2-(di-n-propylamino)tetralin | CHEMBL1788118 | [3H]-8-OH-DPAT | US10562853, Compound 8-OH-DPAT
Type:
radiolabeled ligand
Emp. Form.:
C16H25NO
Mol. Mass.:
247.19
SMILES:
CCCN(CCC)C1CCc2cccc(O)c2C1
Structure:
Search PDB for entries with ligand similarity: