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Target
D(4) dopamine receptor
Ligand
BDBM50487259
Substrate
n/a
Meas. Tech.
ChEMBL_1991793 (CHEMBL4625528)
Ki
0.860000±n/a nM
Citation
 Karki, A; Namballa, HK; Alberts, I; Harding, WW Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HT Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
DOPAMINE D4 | D(2C) dopamine receptor | DOPAMINE D4.4 | DOPAMINE D4.2 | Dopamine D4 receptor | DRD4_HUMAN | DRD4
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Human
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50487259
Synonyms:
CHEBI:64219 | [3H]NEMONAPRIDE
Type:
Small organic molecule
Emp. Form.:
C21H26ClN3O2
Mol. Mass.:
387.91
SMILES:
C[C@@H]1[C@@H](CCN1Cc2ccccc2)NC(=O)c3cc(c(cc3OC)NC)Cl
Structure:
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