Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50101853
Substrate
n/a
Meas. Tech.
ChEMBL_158450 (CHEMBL763254)
Ki
3.3±n/a nM
Citation
 Maruyama, T; Asada, M; Shiraishi, T; Ishida, A; Egashira, H; Yoshida, H; Maruyama, T; Ohuchida, S; Nakai, H; Kondo, K; Toda, M Design and synthesis of a highly selective EP4-receptor agonist. Part 1: 3,7-dithiaPG derivatives with high selectivity. Bioorg Med Chem Lett 11:2029-31 (2001) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PGE receptor, EP4 subtype | PE2R4_MOUSE | Ptger4 | Ptgerep4 | Prostanoid EP4 receptor
Type:
G-protein coupled receptor
Mol. Mass.:
56175.66
Organism:
Mouse
Description:
n/a
Residue:
513
Sequence:
MAEVGGTIPRSNRELQRCVLLTTTIMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAIYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAAAVASVACRGHAGASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPNVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDSSAQHCSESRRTSSAMSGHSRSFLARELKEISSTSQTLLYLPDLTESSLGGRNLLPGSHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSHREEPASKGNSLQVTFPSETLKLSEKCI
  
Inhibitor
Name:
BDBM50101853
Synonyms:
(13E,15S)-11alpha,15-dihydroxy-9-oxoprost-13-en-1-oic acid | prostaglandin E1 | (11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid | 11alpha,15alpha-dihydroxy-9-oxo-13-trans-prostenoic acid | PGE-1 | PGE1 | CHEMBL495 | ALPROSTADIL
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: