Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase Yes
Ligand
BDBM50103788
Substrate
n/a
Meas. Tech.
ChEBML_217596
IC50
>500000±n/a nM
Citation
Kawahata, N; Yang, MG; Luke, GP; Shakespeare, WC; Sundaramoorthi, R; Wang, Y; Johnson, D; Merry, T; Violette, S; Guan, W; Bartlett, C; Smith, J; Hatada, M; Lu, X; Dalgarno, DC; Eyermann, CJ; Bohacek, RS; Sawyer, TK A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain. Bioorg Med Chem Lett 11:2319-23 (2001) [PubMed] Article
More Info.:
Target
Name:
Tyrosine-protein kinase Yes
Synonyms:
Proto-oncogene c-Yes | VHL/Tyrosine-protein kinase Yes | YES | YES1 | YES_HUMAN | p61-yes
Type:
Protein
Mol. Mass.:
60801.54
Organism:
Homo sapiens (Human)
Description:
P07947
Residue:
543
Sequence:
MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL
Inhibitor
Name:
BDBM50103788
Synonyms:
(5-{2-[1-(3-Carbamoyl-4-cyclohexylmethoxy-phenyl)-1-methyl-ethylcarbamoyl]-ethyl}-2-hydroxy-phenyl)-phosphonic acid | CHEMBL76937
Type:
Small organic molecule
Emp. Form.:
C26H35N2O7P
Mol. Mass.:
518.5391
SMILES:
CC(C)(NC(=O)CCc1ccc(O)c(c1)P(O)(O)=O)c1ccc(OCC2CCCCC2)c(c1)C(N)=O