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Target
Signal peptide peptidase-like 2A
Ligand
BDBM50546129
Substrate
n/a
Meas. Tech.
ChEMBL_2014323 (CHEMBL4667901)
IC50
840±n/a nM
Citation
 Velcicky, J; Mathison, CJN; Nikulin, V; Pflieger, D; Epple, R; Azimioara, M; Cow, C; Michellys, PY; Rigollier, P; Beisner, DR; Bodendorf, U; Guerini, D; Liu, B; Wen, B; Zaharevitz, S; Brandl, T Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors. ACS Med Chem Lett 10:887-892 (2019) [PubMed]  Article 
Target
Name:
Signal peptide peptidase-like 2A
Synonyms:
3.4.23.- | IMP-3 | IMP3 | Intramembrane protease 3 | PSL2 | Presenilin-like protein 2 | SPP-like 2A | SPP2A_HUMAN | SPPL2A | Signal peptide peptidase-like 2A
Type:
PROTEIN
Mol. Mass.:
58152.61
Organism:
Homo sapiens
Description:
ChEMBL_117438
Residue:
520
Sequence:
MGPQRRLSPAGAALLWGFLLQLTAAQEAILHASGNGTTKDYCMLYNPYWTALPSTLENATSISLMNLTSTPLCNLSDIPPVGIKSKAVVVPWGSCHFLEKARIAQKGGAEAMLVVNNSVLFPPSGNRSEFPDVKILIAFISYKDFRDMNQTLGDNITVKMYSPSWPNFDYTMVVIFVIAVFTVALGGYWSGLVELENLKAVTTEDREMRKKKEEYLTFSPLTVVIFVVICCVMMVLLYFFYKWLVYVMIAIFCIASAMSLYNCLAALIHKIPYGQCTIACRGKNMEVRLIFLSGLCIAVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTLKLPNFKSCVILLGLLLLYDVFFVFITPFITKNGESIMVELAAGPFGNNEKLPVVIRVPKLIYFSVMSVCLMPVSILGFGDIIVPGLLIAYCRRFDVQTGSSYIYYVSSTVAYAIGMILTFVVLVLMKKGQPALLYLVPCTLITASVVAWRRKEMKKFWKGNSYQMMDHLDCATNEENPVISGEQIVQQ
  
Inhibitor
Name:
BDBM50546129
Synonyms:
CHEMBL4785324
Type:
Small organic molecule
Emp. Form.:
C20H23N3O3S2
Mol. Mass.:
417.545
SMILES:
N[C@H]([C@@H](O)CN(C1CCC1)S(=O)(=O)c1ccc2scnc2c1)c1ccccc1 |r|
Structure:
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