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Target
Sodium/hydrogen exchanger 1
Ligand
BDBM50058759
Substrate
n/a
Meas. Tech.
ChEMBL_141046 (CHEMBL746894)
IC50
3400±n/a nM
Citation
 Ahmad, S; Doweyko, LM; Dugar, S; Grazier, N; Ngu, K; Wu, SC; Yost, KJ; Chen, BC; Gougoutas, JZ; DiMarco, JD; Lan, SJ; Gavin, BJ; Chen, AY; Dorso, CR; Serafino, R; Kirby, M; Atwal, KS Arylcyclopropanecarboxyl guanidines as novel, potent, and selective inhibitors of the sodium hydrogen exchanger isoform-1. J Med Chem 44:3302-10 (2001) [PubMed]  Article 
Target
Name:
Sodium/hydrogen exchanger 1
Synonyms:
APNH | NHE-1 | Na(+)/H(+) antiporter, amiloride-sensitive | Na(+)/H(+) exchanger 1 | Solute carrier family 9 member 1 | SL9A1_HUMAN | SLC9A1 | APNH1 | NHE1
Type:
PROTEIN
Mol. Mass.:
90771.96
Organism:
Human
Description:
ChEMBL_862405
Residue:
815
Sequence:
MVLRSGICGLSPHRIFPSLLVVVALVGLLPVLRSHGLQLSPTASTIRSSEPPRERSIGDVTTAPPEVTPESRPVNHSVTDHGMKPRKAFPVLGIDYTHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYEHVGIVDIFLGFLSFFVVALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVDLVNEELKGKVLGLSRDPAKVAEEDEDDDGGIMMRSKETSSPGTDDVFTPAPSDSPSSQRIQRCLSDPGPHPEPGEGEPFFPKGQ
  
Inhibitor
Name:
BDBM50058759
Synonyms:
CHEMBL436559 | N-(diaminomethylene)-4-isopropyl-3-(methylsulfonyl)benzamide | Cariporide | N-(4-isopropyl-3-methanesulfonyl-benzoyl)-guanidine | CHEMBL462831 | N-(4-Isopropyl-3-methanesulfonyl-benzoyl)-guanidine(Cariporide) | N-(4-Isopropyl-3-methanesulfonyl-benzoyl)-guanidine (Cariporide)
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC(C)c1ccc(cc1S(C)(=O)=O)C(=O)NC(N)=N
Structure:
Search PDB for entries with ligand similarity: