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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50370595
Substrate
n/a
Meas. Tech.
ChEMBL_2022613 (CHEMBL4676426)
Ki
>10000±n/a nM
Citation
 García, M; Virgili, M; Alonso, M; Alegret, C; Farran, J; Fernández, B; Bordas, M; Pascual, R; Burgueño, J; Vidal-Torres, A; Fernández de Henestrosa, AR; Ayet, E; Merlos, M; Vela, JM; Plata-Salamán, CR; Almansa, C Discovery of EST73502, a Dual μ-Opioid Receptor Agonist and σ J Med Chem 63:15508-15526 (2020) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | SIG-1R | SR-BP | SR31747-binding protein | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 | SGMR1_HUMAN | SIGMAR1 | OPRS1 | SRBP
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Human
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50370595
Synonyms:
US9233167, Oxycodone | Oxycontin | OXYCODONE | US1184575, oxycodone
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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