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Target
Delta-type opioid receptor
Ligand
BDBM50108444
Substrate
n/a
Meas. Tech.
ChEBML_145327
IC50
>10000±n/a nM
Citation
 Semple, G; Andersson, BM; Chhajlani, V; Georgsson, J; Johansson, M; Lindschoten, M; Pontén, F; Rosenquist, A; Sörensen, H; Swanson, L; Swanson, M 3-Aryl pyridone derivatives. Potent and selective kappa opioid receptor agonists. Bioorg Med Chem Lett 12:197-200 (2001) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50108444
Synonyms:
1-(1-Phenyl-2-pyrrolidin-1-yl-ethyl)-3-(4-trifluoromethoxy-phenyl)-1H-pyridin-2-one | CHEMBL61426
Type:
Small organic molecule
Emp. Form.:
C24H23F3N2O2
Mol. Mass.:
428.4468
SMILES:
FC(F)(F)Oc1ccc(cc1)-c1cccn(C(CN2CCCC2)c2ccccc2)c1=O
Structure:
Search PDB for entries with ligand similarity: