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Target
Solute carrier family 22 member 6
Ligand
BDBM207624
Substrate
n/a
Meas. Tech.
ChEMBL_2024651 (CHEMBL4678464)
IC50
47800±n/a nM
Citation
 Wang, H; Ren, B; Liu, Y; Jiang, B; Guo, Y; Wei, M; Luo, L; Kuang, X; Qiu, M; Lv, L; Xu, H; Qi, R; Yan, H; Xu, D; Wang, Z; Huo, CX; Zhu, Y; Zhao, Y; Wu, Y; Qin, Z; Su, D; Tang, T; Wang, F; Sun, X; Feng, Y; Peng, H; Wang, X; Gao, Y; Liu, Y; Gong, W; Yu, F; Liu, X; Wang, L; Zhou, C Discovery of Pamiparib (BGB-290), a Potent and Selective Poly (ADP-ribose) Polymerase (PARP) Inhibitor in Clinical Development. J Med Chem 63:15541-15563 (2020) [PubMed]  Article 
Target
Name:
Solute carrier family 22 member 6
Synonyms:
OAT1 | Organic anion transporter 1 | PAH transporter | PAHT | Renal organic anion transporter 1 | S22A6_HUMAN | SLC22A6 | hOAT1 | hPAHT | hROAT1
Type:
PROTEIN
Mol. Mass.:
61831.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1487359
Residue:
563
Sequence:
MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQTRQQQEHQKYMVPLQASAQEKNGL
  
Inhibitor
Name:
BDBM207624
Synonyms:
US10501467, Example 69 | US9260440, 69 | US9617273, Example 69
Type:
Small organic molecule
Emp. Form.:
C16H15FN4O
Mol. Mass.:
298.3149
SMILES:
C[C@]12CCCN1Cc1n[nH]c(=O)c3cc(F)cc4[nH]c2c1c34 |r|
Structure:
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