Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50551242
Substrate
n/a
Meas. Tech.
ChEMBL_2031061 (CHEMBL4685219)
Ki
6.0±n/a nM
Citation
 Temme, L; Bechthold, E; Schreiber, JA; Gawaskar, S; Schepmann, D; Robaa, D; Sippl, W; Seebohm, G; Wünsch, B Negative allosteric modulators of the GluN2B NMDA receptor with phenylethylamine structure embedded in ring-expanded and ring-contracted scaffolds. Eur J Med Chem 190:0 (2020) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Sigma-1 receptor | Sigma1-receptor | Sterol isomerase-like protein | Sigma1R | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | SGMR1_CAVPO | SIGMAR1 | OPRS1
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Guinea pig
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50551242
Synonyms:
CHEMBL4740593
Type:
Small organic molecule
Emp. Form.:
C22H27N
Mol. Mass.:
305.46
SMILES:
C(C1CCN(CC1)C1CCc2ccccc2C1)c1ccccc1
Structure:
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