Target
Endothelin receptor type B
Ligand
BDBM50112679
Substrate
n/a
Meas. Tech.
ChEMBL_63865 (CHEMBL670726)
IC50
1100±n/a nM
Citation
 Ishizuka, NMatsumura, KSakai, KFujimoto, MMihara, SYamamori, T Structure-activity relationships of a novel class of endothelin-A receptor antagonists and discovery of potent and selective receptor antagonist, 2-(benzo[1,3]dioxol-5-yl)-6-isopropyloxy-4-(4-methoxyphenyl)-2H-chromene-3-carboxylic acid (S-1255). 1. Study on structure-activity relationships and bas J Med Chem 45:2041-55 (2002) [PubMed]  Article 
Target
Name:
Endothelin receptor type B
Synonyms:
EDNRB | EDNRB_PIG | Endothelin receptor ET-B
Type:
PROTEIN
Mol. Mass.:
49616.89
Organism:
Sus scrofa
Description:
ChEMBL_63872
Residue:
443
Sequence:
MQPLRSLCGRALVALIFACGVAGVQSEERGFPPAGATPPALRTGEIVAPPTKTFWPRGSNASLPRSSSPPQMPKGGRMAGPPARTLTPPPCEGPIEIKDTFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEALGFDMITTDYKGNRLRICLLHPTQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQNDSNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
  
Inhibitor
Name:
BDBM50112679
Synonyms:
2-Benzo[1,3]dioxol-5-yl-4-pentyloxy-2H-chromene-3-carboxylic acid | CHEMBL293702
Type:
Small organic molecule
Emp. Form.:
C22H22O6
Mol. Mass.:
382.4065
SMILES:
CCCCCOC1=C(C(Oc2ccccc12)c1ccc2OCOc2c1)C(O)=O |t:6|
Structure:
Search PDB for entries with ligand similarity: