Reaction Details Report a problem with these data
Target
Farnesyl pyrophosphate synthase
Ligand
BDBM12581
Substrate
n/a
Meas. Tech.
ChEMBL_69350 (CHEMBL677586)
IC50
200±n/a nM
Citation
 Szabo, CM; Matsumura, Y; Fukura, S; Martin, MB; Sanders, JM; Sengupta, S; Cieslak, JA; Loftus, TC; Lea, CR; Lee, HJ; Koohang, A; Coates, RM; Sagami, H; Oldfield, E Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents. J Med Chem 45:2185-96 (2002) [PubMed]  Article 
Target
Name:
Farnesyl pyrophosphate synthase
Synonyms:
Farnesyl pyrophosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthetase | Dimethylallyltranstransferase | Geranyltranstransferase | Farnesyl diphosphate synthase (FPPS) | FPP synthetase | FPP synthase | P14324 | FPPS_HUMAN | FDPS | FPS | KIAA1293 | Farnesyl diphosphate synthase
Type:
Enzyme
Mol. Mass.:
48272.89
Organism:
Human
Description:
P14324
Residue:
419
Sequence:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
  
Inhibitor
Name:
BDBM12581
Synonyms:
JMC515594 Compound 62 | (3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid | CHEMBL834 | Bisphosphonate 6
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: