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Target
Sorbitol dehydrogenase
Ligand
BDBM50113497
Substrate
n/a
Meas. Tech.
ChEMBL_201005 (CHEMBL801255)
IC50
6±n/a nM
Citation
 Chu-Moyer, MY; Ballinger, WE; Beebe, DA; Coutcher, JB; Day, WW; Li, J; Oates, PJ; Weekly, RM SAR and species/stereo-selective metabolism of the sorbitol dehydrogenase inhibitor, CP-470,711. Bioorg Med Chem Lett 12:1477-80 (2002) [PubMed]  Article 
Target
Name:
Sorbitol dehydrogenase
Synonyms:
L-iditol 2-dehydrogenase | DHSO_HUMAN | SORD
Type:
PROTEIN
Mol. Mass.:
38332.20
Organism:
Human
Description:
ChEMBL_223910
Residue:
357
Sequence:
MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGNLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
  
Inhibitor
Name:
BDBM50113497
Synonyms:
1-(4-{(2S,6R)-4-[2-((R)-1-Hydroxy-ethyl)-pyrimidin-4-yl]-2,6-dimethyl-piperazin-1-yl}-pyrimidin-2-yl)-ethanone | CHEMBL34667
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
C[C@@H](O)c1nccc(n1)N1C[C@H](C)N([C@H](C)C1)c1ccnc(n1)C(C)=O
Structure:
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