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Target
Vasopressin V1a receptor
Ligand
BDBM50114039
Substrate
n/a
Meas. Tech.
ChEMBL_214412 (CHEMBL820276)
Ki
13.9±n/a nM
Citation
 Kakefuda, A; Suzuki, T; Tobe, T; Tsukada, J; Tahara, A; Sakamoto, S; Tsukamoto, S Synthesis and pharmacological evaluation of 5-(4-biphenyl)-3-methyl-4-phenyl-1,2,4-triazole derivatives as a novel class of selective antagonists for the human vasopressin V(1A) receptor. J Med Chem 45:2589-98 (2002) [PubMed]  Article 
Target
Name:
Vasopressin V1a receptor
Synonyms:
AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
46820.18
Organism:
Homo sapiens (Human)
Description:
P37288
Residue:
418
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
  
Inhibitor
Name:
BDBM50114039
Synonyms:
1-{6-[2-(3-Biphenyl-4-yl-5-methyl-[1,2,4]triazol-4-yl)-phenoxy]-hexyl}-piperidine | CHEMBL87455
Type:
Small organic molecule
Emp. Form.:
C32H38N4O
Mol. Mass.:
494.6703
SMILES:
Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1OCCCCCCN1CCCCC1 |(9.29,-1.39,;7.83,-1.97,;6.55,-1.15,;5.37,-2.08,;5.92,-3.51,;5.02,-4.76,;5.68,-6.17,;4.76,-7.42,;3.23,-7.27,;2.58,-5.86,;3.49,-4.61,;2.33,-8.52,;2.97,-9.93,;2.07,-11.18,;.52,-11.06,;-.12,-9.64,;.78,-8.39,;7.45,-3.44,;8.55,-4.53,;8.14,-5.99,;9.24,-7.08,;10.72,-6.68,;11.12,-5.22,;10.03,-4.13,;10.44,-2.63,;11.94,-2.23,;12.33,-.75,;13.82,-.36,;14.22,1.13,;15.68,1.53,;16.09,3.01,;17.57,3.39,;18.67,2.32,;20.12,2.71,;20.53,4.19,;19.44,5.28,;17.96,4.88,)|
Structure:
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