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Target
Vasopressin V2 receptor
Ligand
BDBM50114035
Substrate
n/a
Meas. Tech.
ChEMBL_214718 (CHEMBL817919)
Ki
2460±n/a nM
Citation
 Kakefuda, A; Suzuki, T; Tobe, T; Tsukada, J; Tahara, A; Sakamoto, S; Tsukamoto, S Synthesis and pharmacological evaluation of 5-(4-biphenyl)-3-methyl-4-phenyl-1,2,4-triazole derivatives as a novel class of selective antagonists for the human vasopressin V(1A) receptor. J Med Chem 45:2589-98 (2002) [PubMed]  Article 
Target
Name:
Vasopressin V2 receptor
Synonyms:
Vasopressin receptor | Vasopressin V2 receptor | AVPR V2 | Antidiuretic hormone receptor | Renal-type arginine vasopressin receptor | VASOPRESSIN V2 | V2R_HUMAN | AVPR2 | ADHR | DIR | DIR3 | V2R
Type:
Receptor
Mol. Mass.:
40295.28
Organism:
Human
Description:
P30518
Residue:
371
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
  
Inhibitor
Name:
BDBM50114035
Synonyms:
3-Biphenyl-4-yl-4-(2-methoxy-phenyl)-5-methyl-4H-[1,2,4]triazole | CHEMBL87351
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COc1ccccc1-n1c(C)nnc1-c1ccc(cc1)-c1ccccc1 |(18.22,-5.11,;16.73,-4.71,;15.64,-5.81,;16.04,-7.28,;14.95,-8.38,;13.47,-7.98,;13.07,-6.5,;14.17,-5.41,;13.77,-3.93,;14.8,-2.77,;16.34,-2.77,;14.01,-1.43,;12.51,-1.76,;12.35,-3.3,;11.02,-4.08,;9.68,-3.32,;8.36,-4.1,;8.37,-5.63,;9.7,-6.41,;11.04,-5.63,;7.04,-6.41,;7.04,-7.96,;5.69,-8.73,;4.36,-7.96,;4.36,-6.41,;5.69,-5.64,)|
Structure:
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