Reaction Details Report a problem with these data
Target
Vasopressin V2 receptor
Ligand
BDBM50114044
Substrate
n/a
Meas. Tech.
ChEMBL_214718 (CHEMBL817919)
Ki
8170±n/a nM
Citation
Kakefuda, A; Suzuki, T; Tobe, T; Tsukada, J; Tahara, A; Sakamoto, S; Tsukamoto, S Synthesis and pharmacological evaluation of 5-(4-biphenyl)-3-methyl-4-phenyl-1,2,4-triazole derivatives as a novel class of selective antagonists for the human vasopressin V(1A) receptor. J Med Chem 45:2589-98 (2002) [PubMed] Article
More Info.:
Target
Name:
Vasopressin V2 receptor
Synonyms:
ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
40295.28
Organism:
Human
Description:
P30518
Residue:
371
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
Inhibitor
Name:
BDBM50114044
Synonyms:
4-{2-[2-(3-Biphenyl-4-yl-5-methyl-[1,2,4]triazol-4-yl)-phenoxy]-ethyl}-piperidine | CHEMBL315251
Type:
Small organic molecule
Emp. Form.:
C28H30N4O
Mol. Mass.:
438.564
SMILES:
Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1OCCC1CCNCC1 |(12.17,-.12,;10.79,-.82,;9.49,.02,;8.3,-.94,;8.86,-2.39,;8.02,-3.68,;6.47,-3.61,;5.64,-4.89,;6.34,-6.26,;7.87,-6.34,;8.71,-5.05,;5.5,-7.55,;6.2,-8.93,;5.35,-10.22,;3.81,-10.14,;3.11,-8.75,;3.96,-7.46,;10.4,-2.31,;11.41,-3.46,;10.92,-4.91,;11.94,-6.06,;13.44,-5.75,;13.93,-4.28,;12.9,-3.14,;13.39,-1.68,;14.76,-1,;16.05,-1.85,;15.96,-3.4,;14.56,-4.07,;14.47,-5.61,;15.75,-6.46,;17.13,-5.78,;17.24,-4.24,)|