Target
Melatonin receptor type 1B
Ligand
BDBM50114701
Substrate
n/a
Meas. Tech.
ChEMBL_105263 (CHEMBL715855)
Ki
0.11±n/a nM
Citation
 Wallez, VDurieux-Poissonnier, SChavatte, PBoutin, JAAudinot, VNicolas, JPBennejean, CDelagrange, PRenard, PLesieur, D Synthesis and structure-affinity-activity relationships of novel benzofuran derivatives as MT(2) melatonin receptor selective ligands. J Med Chem 45:2788-800 (2002) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1B
Synonyms:
MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2)
Type:
Enzyme
Mol. Mass.:
40203.54
Organism:
Homo sapiens (Human)
Description:
P49286
Residue:
362
Sequence:
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
  
Inhibitor
Name:
BDBM50114701
Synonyms:
But-3-enoic acid {2-[5-methoxy-2-(3-methoxy-benzyl)-benzofuran-3-yl]-ethyl}-amide | CHEMBL329086
Type:
Small organic molecule
Emp. Form.:
C23H25NO4
Mol. Mass.:
379.4489
SMILES:
COc1cccc(Cc2oc3ccc(OC)cc3c2CCNC(=O)CC=C)c1
Structure:
Search PDB for entries with ligand similarity: