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Target
Palmitoleoyl-protein carboxylesterase NOTUM
Ligand
BDBM50361164
Substrate
n/a
Meas. Tech.
ChEMBL_2049890 (CHEMBL4704589)
IC50
170±n/a nM
Citation
 Mahy, W; Willis, NJ; Zhao, Y; Woodward, HL; Svensson, F; Sipthorp, J; Vecchia, L; Ruza, RR; Hillier, J; Kjær, S; Frew, S; Monaghan, A; Bictash, M; Salinas, PC; Whiting, P; Vincent, JP; Jones, EY; Fish, PV 5-Phenyl-1,3,4-oxadiazol-2(3 J Med Chem 63:12942-12956 (2020) [PubMed]  Article 
Target
Name:
Palmitoleoyl-protein carboxylesterase NOTUM
Synonyms:
NOTUM | NOTUM_HUMAN | Palmitoleoyl-protein carboxylesterase NOTUM | hNOTUM
Type:
PROTEIN
Mol. Mass.:
55706.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116492
Residue:
496
Sequence:
MGRGVRVLLLLSLLHCAGGSEGRKTWRRRGQQPPPPPRTEAAPAAGQPVESFPLDFTAVEGNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRWLLFLEGGWYCFNRENCDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFIPYCSSDVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTGVLLNVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITCAPTEAIRRGIRYWNGVVPERCRRQFQEGEEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGLRLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSLHDSHKASKTPLKGCPVHLVDSCPWPHCNPSCPTVRDQFTGQEMNVAQFLMHMGFDMQTVAQPQGLEPSELLGMLSNGS
  
Inhibitor
Name:
BDBM50361164
Synonyms:
CHEMBL4174188
Type:
Small organic molecule
Emp. Form.:
C22H21ClN4O5
Mol. Mass.:
456.879
SMILES:
Clc1ccc(CN2CCN3C(C2)C(=O)N(OC(=O)N2CCOc4ccccc24)C3=O)cc1
Structure:
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