Target
Substance-P receptor
Ligand
BDBM50403919
Substrate
n/a
Meas. Tech.
ChEBML_205391
IC50
6±n/a nM
Citation
 Mah, RGerspacher, Mvon Sprecher, AStutz, STschinke, VAnderson, GPBertrand, CSubramanian, NBall, HA Biphenyl derivatives as novel dual NK(1)/NK(2)-receptor antagonists. Bioorg Med Chem Lett 12:2065-8 (2002) [PubMed]  Article
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50403919
Synonyms:
CHEMBL2112211
Type:
Small organic molecule
Emp. Form.:
C30H27F6N3O3
Mol. Mass.:
591.5441
SMILES:
CN(C(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1cc(ccc1-c1ccc(C)cc1)C(=O)N[C@@H]1CCCCNC1=O |r|
Structure:
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