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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50118325
Substrate
n/a
Meas. Tech.
ChEMBL_201963 (CHEMBL809149)
Ki
9.9±n/a nM
Citation
 Orús, L; Pérez-Silanes, S; Oficialdegui, AM; Martínez-Esparza, J; Del Castillo, JC; Mourelle, M; Langer, T; Guccione, S; Donzella, G; Krovat, EM; Poptodorov, K; Lasheras, B; Ballaz, S; Hervías, I; Tordera, R; Del Río, J; Monge, A Synthesis and molecular modeling of new 1-aryl-3-[4-arylpiperazin-1-yl]-1-propane derivatives with high affinity at the serotonin transporter and at 5-HT(1A) receptors. J Med Chem 45:4128-39 (2002) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor
Type:
Multi-pass membrane protein
Mol. Mass.:
70168.43
Organism:
Rattus norvegicus (rat)
Description:
P31652
Residue:
630
Sequence:
METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
  
Inhibitor
Name:
BDBM50118325
Synonyms:
1-Benzo[b]thiophen-3-yl-3-[4-(1,2-dihydro-quinolin-2-yl)-piperazin-1-yl]-propan-1-ol | CHEMBL131691
Type:
Small organic molecule
Emp. Form.:
C24H27N3OS
Mol. Mass.:
405.556
SMILES:
OC(CCN1CCN(CC1)C1Nc2ccccc2C=C1)c1csc2ccccc12 |c:20|
Structure:
Search PDB for entries with ligand similarity: