Reaction Details Report a problem with these data
Target
Ribosyldihydronicotinamide dehydrogenase [quinone]
Ligand
BDBM50118451
Substrate
n/a
Meas. Tech.
ChEMBL_104940 (CHEMBL714719)
Ki
1770±n/a nM
Citation
 Fukatsu, K; Uchikawa, O; Kawada, M; Yamano, T; Yamashita, M; Kato, K; Hirai, K; Hinuma, S; Miyamoto, M; Ohkawa, S Synthesis of a novel series of benzocycloalkene derivatives as melatonin receptor agonists. J Med Chem 45:4212-21 (2002) [PubMed]  Article 
Target
Name:
Ribosyldihydronicotinamide dehydrogenase [quinone]
Synonyms:
Metallothionein-3 | NMOR2 | NQO2 | NQO2_HUMAN | NRH dehydrogenase [quinone] 2 | NRH:quinone oxidoreductase 2 | QR2 | Quinone reductase 2 | Quinone reductase 2 (NQO2) | Ribosyldihydronicotinamide dehydrogenase [quinone]
Type:
Protein
Mol. Mass.:
25917.25
Organism:
Homo sapiens (Human)
Description:
P16083
Residue:
231
Sequence:
MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ
  
Inhibitor
Name:
BDBM50118451
Synonyms:
2,2,2-Trifluoro-N-[2-(6-methoxy-2-phenyl-indan-1-yl)-ethyl]-acetamide | CHEMBL134544
Type:
Small organic molecule
Emp. Form.:
C20H20F3NO2
Mol. Mass.:
363.3735
SMILES:
COc1ccc2CC(C(CCNC(=O)C(F)(F)F)c2c1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: