Reaction Details Report a problem with these data
Target
DNA-binding protein Ikaros/Protein cereblon
Ligand
BDBM50557457
Substrate
n/a
Meas. Tech.
ChEMBL_2059191 (CHEMBL4714192)
EC50
>10000±n/a nM
Citation
Hansen, JD; Correa, M; Alexander, M; Nagy, M; Huang, D; Sapienza, J; Lu, G; LeBrun, LA; Cathers, BE; Zhang, W; Tang, Y; Ammirante, M; Narla, RK; Piccotti, JR; Pourdehnad, M; Lopez-Girona, A CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia. J Med Chem 64:1835-1843 (2021) [PubMed] Article
More Info.:
Target
Name:
DNA-binding protein Ikaros/Protein cereblon
Synonyms:
Cereblon/Ikaros
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 2059191
Components:
This complex has 2 components.
Component 1
Name:
Protein cereblon
Synonyms:
CRBN | CRBN_HUMAN | Protein cereblon
Type:
PROTEIN
Mol. Mass.:
50537.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116917
Residue:
442
Sequence:
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
Component 2
Name:
DNA-binding protein Ikaros
Synonyms:
DNA-binding protein Ikaros | IK1 | IKAROS | IKZF1 | IKZF1_HUMAN | Ikaros family zinc finger protein 1 | LYF1 | Lymphoid transcription factor LyF-1 | ZNFN1A1
Type:
PROTEIN
Mol. Mass.:
57528.78
Organism:
Homo sapiens
Description:
ChEMBL_120150
Residue:
519
Sequence:
MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVASNVKVETQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCDICGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGTLYPVIKEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYEKENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPRSNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAPHARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS