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Target
Growth factor receptor-bound protein 2
Ligand
BDBM50118687
Substrate
n/a
Meas. Tech.
ChEMBL_72355 (CHEMBL686442)
IC50
8±n/a nM
Citation
 Wei, CQ; Li, B; Guo, R; Yang, D; Burke, TR Development of a phosphatase-stable phosphotyrosyl mimetic suitably protected for the synthesis of high-affinity Grb2 SH2 domain-binding ligands. Bioorg Med Chem Lett 12:2781-4 (2002) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
Grb2-SH2 | GRB2 adapter protein | Growth factor receptor-bound protein 2 | GRB2_HUMAN | GRB2 | ASH
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Human
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50118687
Synonyms:
N-{1-[(S)-2-Carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexyl}-3-((R)-3-phosphonomethyl-benzyl)-succinamic acid | (R)-N-{1-[(S)-2-Carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexyl}-3-(4-phosphonomethyl-benzyl)-succinamic acid | CHEMBL93367
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
NC(=O)C[C@H](NC(=O)C1(CCCCC1)NC(=O)[C@@H](CC(O)=O)Cc1ccc(CP(O)(O)=O)cc1)C(=O)NCCCc1cccc2ccccc12
Structure:
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