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Target
D(2) dopamine receptor
Ligand
BDBM50558340
Substrate
n/a
Meas. Tech.
ChEMBL_2063305 (CHEMBL4718558)
Ki
12±n/a nM
Citation
 Stefanowicz, J; S?owi?ski, T; Wróbel, MZ; Herold, F; Gomó?ka, AE; Weso?owska, A; Jastrz?bska-Wi?sek, M; Partyka, A; Andres-Mach, M; Czuczwar, SJ; ?uszczki, JJ; Zagaja, M; Siwek, A; Nowak, G; ?o?nierek, M; B?czek, T; Ulenberg, S; Belka, M; Tur?o, J Synthesis and biological investigation of new equatorial (?) stereoisomers of 3-aminotropane arylamides with atypical antipsychotic profile. Bioorg Med Chem 24:3994-4007 (2016) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50558340
Synonyms:
CHEMBL4752931
Type:
Small organic molecule
Emp. Form.:
C25H25BrN2O
Mol. Mass.:
449.383
SMILES:
Brc1cccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)c1 |TLB:6:7:13.14.12:9.10|
Structure:
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